0.5ml for cats Selamectin and Sarolaner Drops

Selamectin and Sarolaner Drops for cat is a kind of pet deworming drops that combines Selamectin with Sarolaner to enhance the killing effect and provide long-lasting protection for peace of mind. De-worming is essential. This product is the roundworm medicine for cats and treat flea for cats,that is the effective worming drops for cats.To protect your cat’s health, please regularly de-worm your cat.It can treat flea for cats.

Pharmacodynamics: Selamectin is a semi-synthetic compound of avermectins, which can make parasite neurons long-lasting superpolar by activating and/or enhancing glutamate-mediated chloride channel (GluCl) in invertebrates changes, disrupting its normal neurotransmission, resulting in paralysis, death or expulsion of the worm.

Sarolaner is an isoxazoline compound, mainly by blocking the γ-aminobutyric acid-mediated chloride ion channel (GABACl) in the central nervous system of insects and acarids, so as to prevent the influx of chloride ions, and nerve stimulation triggers nerve excitation increase, resulting in the death of the parasite.

Selamectin and Sarolaner have different mechanisms of action on GluCl and GABACl respectively, but the two will not interfere pharmacologically, selamectin exerts a functional blocking effect, and sarollana exerts a channel activity blocking effect , and synergistically destroy the nerve and muscle tissue functions of invertebrates, making the anthelmintic activity enhanced. Therefore, this product has a broad-spectrum anthelmintic effect, and can prevent and control internal and external parasites in cats.

Pharmacokinetics: The mean bioavailability of selamectin and Sarolaner are 40.5% and 57.9%, respectively, and can be distributed systemically. Selamectin and Sarolaner have long half-lives in cats, 12.5 days and 41.5 days, respectively. In cats, selamectin is mainly eliminated in the feces as the original form, and salolana is mainly eliminated in the unchanged form through the bile and feces.

Specification:0.5ml: 30mg+5mg

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Parasites are ubiquitous

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